Functional Expression of Mammalian Odorant Receptors
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منابع مشابه
Functional Expression of Mammalian Odorant Receptors
The olfactory sensory neurons (OSNs) in the olfactory epithelium of the nose detect and discriminate a large number of volatile environmental chemicals. This ability is essential for animals to find prey, food, mates, predators and toxic compounds. In OSNs, odorant receptor (OR) proteins, members of the G-protein coupled receptor (GPCR) superfamily, are concentrated at the membrane of the cilia...
متن کاملRTP Family Members Induce Functional Expression of Mammalian Odorant Receptors
Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical in order for the receptors to recognize their ligands. However, mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. Here we show that the transmembrane proteins RTP1 and RTP2 promote functional cell surface expression of ORs expressed in...
متن کاملFunctional Evolution of Mammalian Odorant Receptors
The mammalian odorant receptor (OR) repertoire is an attractive model to study evolution, because ORs have been subjected to rapid evolution between species, presumably caused by changes of the olfactory system to adapt to the environment. However, functional assessment of ORs in related species remains largely untested. Here we investigated the functional properties of primate and rodent ORs t...
متن کاملThe Functional Evolution of Mammalian Odorant Receptors
The Functional Evolution of Mammalian Odorant Receptors by Kaylin Alexis Adipietro University Program in Genetics and Genomics Duke University Date:_______________________ Approved: ___________________________ Hiroaki Matsunami, Supervisor ___________________________ Marc Caron ___________________________ William Dan Tracey ___________________________ Christine Drea ___________________________ ...
متن کاملFunctional expression of a mammalian odorant receptor.
Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recordi...
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ژورنال
عنوان ژورنال: Chemical Senses
سال: 2005
ISSN: 0379-864X,1464-3553
DOI: 10.1093/chemse/bjh131